FIGURE

Fig. 4

ID

ZDB-FIG-220926-12

Publication

Zoodsma et al., 2022 - Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

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Fig. 4

Zebrafish lacking fmr1, but not other NMDAR subunits, show a social preference deficit at 3 wpf. A SPI from a 3 wpf assay on fish lacking fmr1. Experimental details in Additional file 1: Table S4. B Bar graph (mean ± SEM) outlining mean time spent in each of the zone subdivisions for each fmr1 genotype at 3 wpf. Dashed line is at 25%, the value of no preference for any zone. Zone 4 is the region closest to the conspecific. C SPI from 3 wpf assays of zebrafish lacking grin1a, grin1b, grin2A, grin2Da, and grin2Db. Dashed line is at 0, the value of no preference in SPI. Experimental details in Additional file 1: Table S4

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	grin1a^sbu90/sbu90 grin1b^sbu93/sbu93 grin2da^{sbu329/sbu329} grin2db^{sbu330/sbu330} grin2ab^{sbu300/sbu300}; grin2aa^sbu97/sbu97
Observed In:	social behavior
Stage Range:	Days 14-20 to Days 21-29

Phenotype Detail

Acknowledgments

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