FIGURE

Fig. 7

ID

ZDB-FIG-210504-22

Publication

Peng et al., 2020 - Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration

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Fig. 7

Inhibition of Pak2 activity impairs CM dedifferentiation and proliferation. (A) Schematic of heat shock experiments and FRAX597 treatment for PCNA/Mef2C analyses. Heat shock: 37�C for 2 h daily from 4 to 6 dpa for PCNA/Mef2C assay or over the time period from 4 to 30 dpa for AFOG analysis; treatment: 1 �M FRAX597 or 0.1% DMSO from 4 to 6 dpa. (B?D) Confocal image analyses displaying PCNA+Mef2C+ cells (arrowheads, B and C) and PCNA-labeled CM proliferation index (D) in Ctrl and Tg(hsp:dnpak2a) hearts at 7 dpa. Insets indicate high-magnification images in dash-lined areas. Data are mean � SEM from five hearts for each group. Student?s t-test, **P?

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Mol. Cell Biol.