FIGURE

Fig. 4

ID

ZDB-FIG-210428-97

Publication

Xia et al., 2021 - A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish

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Fig. 4

Cell–cell interaction network between HSPCs and nonhematopoietic niche components. (A) The interaction network of TFs of each component. All differentially expressed TFs in each cell type are used to construct network; nodes (TFs) with more than one edge are shown. (B) Dot plot showing the frequency of ligand–receptor genes involved in Kyoto Encyclopedia of Genes and Genomes pathways. (C) Dot plot showing the ligand (red)–receptor (black) pairs between HSPCs and ECs, EC-like cells, fibroblasts, neural cells, epidermal cells, and epithelial cells. (D) Violin plot showing the normalized expression of the ligand and its receptor genes in HSPCs and ECs, fibroblasts, neural cells, spinal cord cells, epidermis, and epithelial cells for each indicated pairing. (E) WISH indicating the expression patterns of ccr9a, notch2, and ptprr in HSPCs, ccl25b and dll4 in ECs, and fgfr2 in fibroblasts at 3.5 dpf. (Scale bar, 100 μm.)

Expression Data

Genes:	ccl25b ccr9a dll4 fgfr2 notch2 ptprr
Fish:	AB/TU
Anatomical Terms:	caudal hematopoietic tissue endothelial cell fibroblast hematopoietic multipotent progenitor cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	la2Tg; s896Tg
Observed In:	caudal hematopoietic tissue cell-cell signaling
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA