FIGURE

Figure 3

ID

ZDB-FIG-200718-49

Publication

Özcan et al., 2020 - Sleep is bi-directionally modified by amyloid beta oligomers

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Figure 3

(A-D’) Exemplar 24 hr traces comparing the effects of Aβshort oligomers on average waking activity (A-D) and sleep (A’-D’) versus Aβrev injected into wild type (A,A’), adrb2a-/- (B,B’), pgrmc1-/- (C,C’), and prp1-/-;prp2-/- mutants (D,D’). (E-H) The effect of Aβshort relative to Aβrev on normalized waking activity (E and F) and sleep (G and H) during the first day is shown. Each dot represents a single larva normalized to the mean of the Aβrev control, and error bars indicate ± SEM. The mean difference effect size and 95% confidence interval are plotted below. N = the number of larvae. The wake inducing and sleep suppressing effects of Aβshort are absent in (E,G) adrb2a-/- and pgrmc1-/- but enhanced in prp1-/-;prp2-/- mutants (F,H). nsp>0.05, *p≤0.05, **p≤0.01, ***p≤0.0001, ****p≤10–5 one-way ANOVA. Data is pooled from n = 2 independent experiments for adrb2a-/-and pgrmc1-/- and n = 3 for prp1-/-;prp2-/-. See also Figure 3—figure supplements 1 and 2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT adrb2a^u511/u511 pgrmc1^u512/u512 prnpb^{ua5003/ua5003}; prnprs3^{ua5001/ua5001}
Condition:	chemical treatment by injection: amyloid-beta
Observed In:	sleep
Stage:	Day 6

Phenotype Detail

Acknowledgments

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