FIGURE

Fig. 2.

ID

ZDB-FIG-200703-27

Publication

Sam et al., 2020 - Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis

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Fig. 2.

The gata4 mutants are viable to adulthood, but develop an age-dependent cardiomyopathy. (A) Representative western blot showing the absence of Gata4 protein in dissected adult gata4^−/− heart tissue. (B) Quantification by qPCR of gata4/5/6 expression reveals a significant upregulation of gata6 mRNA in gata4^−/− embryos at the 50% epiboly stage. (C–G) Ventricles dissected from adult wild-type fish, representing phenotypically normal hearts. (C′–G′) Similarly dissected hearts from 10-month-old gata4^−/− adults show severe cardiomyopathy and an enlarged ventricular chamber. Scale bar: 1 mm.

Expression Data

Genes:	gata4 gata5 gata6
Fish:	WT gata4^wcm5/wcm5 gata4^wcm6/wcm6
Anatomical Terms:	heart whole organism
Stage Range:	50%-epiboly to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gata4^wcm5/wcm5 gata4^wcm6/wcm6
Observed In:	cardiac ventricle heart whole organism
Stage Range:	50%-epiboly to Adult

Phenotype Detail

Acknowledgments

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