FIGURE

Fig. 5.

ID

ZDB-FIG-200703-30

Publication

Sam et al., 2020 - Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis

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Fig. 5.

Loss of gata4 and gata6 results in heart tube morphogenesis defects. ISH was performed using offspring from a gata4^+/−, gata6^+/− in-cross and probes targeting either myocardial marker myl7 or cardiac progenitor marker nkx2.5. (A) The gata4 and gata6 genes are partially redundant for heart tube elongation and looping. The gata4^−/−, gata6^−/− mutants display distinctly truncated and linear heart tubes. Representative scale bars in WT panels: 0.1 mm. (B) Loss of gata4 and/or gata6 does not affect cardiac specification. Error bars shown are s.e.m. (C) Schematic showing that combinatorial loss of gata4 and gata6 impairs the heart tube elongation stage of cardiogenesis.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gata5^wcm8/wcm8; gata4^wcm6/+
Observed In:	embryonic heart tube elongation heart looping heart tube
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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