Gene

gata6

ID

ZDB-GENE-000622-1

Name

GATA binding protein 6

Symbol

gata6 Nomenclature History

Previous Names

GATA-5
cb603 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Exhibits DNA binding activity. Involved in animal organ development; digestive tract development; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Is expressed in several structures, including cardiovascular system; digestive system; endoderm; mesoderm; and yolk syncytial layer. Orthologous to human GATA6 (GATA binding protein 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

91 figures from 66 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb603 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gata6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
atrial heart septal defect 9	Alliance	Atrial septal defect 9	614475
atrioventricular septal defect	Alliance	Atrioventricular septal defect 5	614474
double outlet right ventricle	Alliance	Persistent truncus arteriosus	217095
pancreatic hypoplasia-diabetes-congenital heart disease syndrome	Alliance	Pancreatic agenesis and congenital heart defects	600001
tetralogy of Fallot	Alliance	Tetralogy of Fallot	187500

Associated With gata6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000679	Zinc finger, GATA-type
Domain	IPR008013	GATA-type transcription activator, N-terminal
Family	IPR039355	Transcription factor GATA
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type

Domain Details Per Protein

Protein	Length	GATA-type transcription activator, N-terminal	Transcription factor GATA	Zinc finger, GATA-type	Zinc finger, NHR/GATA-type
UniProtKB:Q6NW63 InterPro	501
UniProtKB:A0A8M6Z1Y8 InterPro	496

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gata6-201 (1) Ensembl	Ensembl	2,054 nt	Select Tool
mRNA	gata6-202 (1) Ensembl	Ensembl	2,427 nt	Select Tool
mRNA	gata6-203 (1) Ensembl	Ensembl	1,797 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations