FIGURE

Fig. 6.

ID

ZDB-FIG-200703-31

Publication

Sam et al., 2020 - Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis

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Fig. 6.

Cardiac development depends on the dosage of gata4/5/6 alleles. ISH was performed using offspring from crossing gata4^+/−, gata5^+/−, gata6^+/− triple heterozygous adults and a probe targeting myocardial marker myl7. (A,A′) Triple heterozygous embryos display abnormal heart tube morphology compared to wild-type siblings, although they can survive to adulthood. Loss of a single gata5 or gata6 allele in a gata4^−/−, gata6^−/− (B,B′) or gata4^−/−, gata5^−/− (C,C′) background, respectively, results in a severe loss of cardiac tissue. Representative scale bar in WT panel: 0.1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gata5^wcm8/wcm8; gata4^wcm6/wcm6 gata5^wcm8/+; gata6^wcm7/+; gata4^wcm6/+ gata5^wcm8/+; gata6^wcm7/wcm7; gata4^wcm6/wcm6 gata5^wcm8/wcm8; gata6^wcm7/+; gata4^wcm6/wcm6
Observed In:	heart tube
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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