FIGURE

Fig. 4.

ID

ZDB-FIG-200205-31

Publication

Tseng et al., 2020 - Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos

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Fig. 4.

Knockdown of either zebrafish lrrc8a paralog perturbed the inflation of the brain ventricle. (A) The inflation of the brain ventricle was impaired in lrrc8a morphants. Scale bars: 200 µm. (B,C) The DMv area size was significantly reduced in lrrc8aa-MO e2i2 (aMO) and lrrc8ab-MO e2i2 (bMO) morphants compared to untreated embryos and control morphants (cMO). The sample size (n) of each group is indicated on top of the histogram. (D,E) The mean value minus two standard deviations of the untreated embryos was defined as the lower normal boundary (4.3507, red dotted line in B,C). Both lrrc8aa-MO e2i2 and lrrc8ab-MO e2i2 resulted in significantly lower normal rate compared to the untreated embryos and control morphants. Different letters on top of the histograms represent different statistical groups (P<0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-lrrc8ab AB + MO3-lrrc8aa
Knockdown Reagents:	MO1-lrrc8ab MO3-lrrc8aa
Observed In:	tectal ventricle third ventricle ventricular system
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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