FIGURE

Figure 7

ID

ZDB-FIG-200129-33

Publication

Yang et al., 2019 - Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model

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Figure 7

Validation of microarray with qPCR for the representative genes. Expression of (A,F) scd, (B,G) gck, (C,H) acat2, (D,I) pik3ca, and (E,J) aldh7a1 in WT, HBx(p53-), Src(p53-), and HBx,Src(p53-) fish after eight weeks of normal diet (NOR), overfeeding (diet-induced obesity, DIO), or high-fat diet (FAT) from (A–E) microarray and (F–J) qPCR analysis. (K) Top 14 genes selected by global omics data analysis. (L) Among the 14 genes, 5 genes (red) overexpressed in WT diet-induced obesity are related to glucose and lipid metabolism. The number of fish is 20 for each group, and the number of experimental replicates for qPCR analysis is 3.

Expression Data

Genes:	acat2 aldh7a1 gck pik3ca scd
Fish:	AB tp53^zdf1/zdf1; nn1002Tg tp53^zdf1/zdf1; nn1003Tg tp53^zdf1/zdf1; nn1002Tg; nn1003Tg
Conditions:	increased food availability high fat
Anatomical Term:	liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB tp53^zdf1/zdf1; nn1002Tg tp53^zdf1/zdf1; nn1003Tg tp53^zdf1/zdf1; nn1002Tg; nn1003Tg
Conditions:	increased food availability high fat
Observed In:	liver
Stage:	Adult

Phenotype Detail

Acknowledgments

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