FIGURE

Figure 4

ID

ZDB-FIG-200129-30

Publication

Yang et al., 2019 - Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model

Other Figures

All Figure Page

Back to All Figure Page

Figure 4

Histopathological changes in various genetic background zebrafish fed with different diets. Representative H&E stain images and histopathologic change statistics of (A–D) WT, (E–H) HBx(p53-), (I–L) Src(p53-), and (M–P) HBx,Src(p53-) fish after 16 weeks of normal diet (NOR), overfeeding (diet-induced obesity, DIO), or high-fat diet (FAT) starting at 3 months of age, and scarified at 7 months. The histopathologic change consists of percentages in five states: normal, steatosis, hyperplasia, dysplasia, and hepatocellular carcinoma (HCC). The number of fish is represented as N on top of each bar. The scale bar is 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB tp53^zdf1/zdf1; nn1002Tg tp53^zdf1/zdf1; nn1003Tg tp53^zdf1/zdf1; nn1002Tg; nn1003Tg
Conditions:	increased food availability high fat
Observed In:	liver liver hepatocellular carcinoma liver hepatocyte liver lipid
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cancers