FIGURE

Figure 1 figure supplement 1

ID

ZDB-FIG-191230-1602

Publication

Park et al., 2019 - CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity

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Figure 1 figure supplement 1

Arterio-venous identity was altered in <italic>ccn1</italic> MO embryos.

In situ hybridization of Notch-1b and Flt-4 was performed at 32 hpf in control and ccn1 MO-injected zebrafish embryos. The expression of Notch-1b was normally in neural tube (NT), DA and ISV and Flt-4 was in PCV. However, in the ccn1 morphants, Notch-1b expression was markedly decreased at DA and ISV and Flt-4, venous markers, was expressed both in DA and PCV. Scale bar = 50 µm.

Expression Data

Genes:	flt4 notch1b
Fish:	AB AB + MO1-ccn1l2 AB + MO2-ccn1l2
Knockdown Reagents:	MO1-ccn1l2 MO2-ccn1l2
Anatomical Terms:	dorsal aorta intersegmental vessel posterior cardinal vein spinal cord
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-ccn1l2 AB + MO2-ccn1l2
Knockdown Reagents:	MO1-ccn1l2 MO2-ccn1l2
Observed In:	dorsal aorta intersegmental vessel
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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