FIGURE

Figure 1

ID

ZDB-FIG-191230-1601

Publication

Park et al., 2019 - CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity

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Figure 1

Arterio-venous identity was altered in <italic>ccn1</italic> MO embryos.

In situ hybridization of Notch-1b and Flt-4 was performed at 32 hpf in control and ccn1 MO-injected zebrafish embryos. The expression of Notch-1b was normally in neural tube (NT), DA and ISV and Flt-4 was in PCV. However, in the ccn1 morphants, Notch-1b expression was markedly decreased at DA and ISV and Flt-4, venous markers, was expressed both in DA and PCV. Scale bar = 50 µm.

Expression Data

Genes:	EGFP fli1
Fish:	AB AB + MO1-ccn1l2 AB + MO2-ccn1l2 s843Tg s843Tg + MO1-ccn1l2 s843Tg + MO2-ccn1l2
Knockdown Reagents:	MO1-ccn1l2 MO2-ccn1l2
Anatomical Terms:	cranial vasculature endothelial cell trunk trunk vasculature whole organism anterior-posterior axis
Stage Range:	Prim-5 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-ccn1l2 AB + MO2-ccn1l2 s843Tg + MO1-ccn1l2 s843Tg + MO2-ccn1l2
Knockdown Reagents:	MO1-ccn1l2 MO2-ccn1l2
Observed In:	cranial vasculature sprouting angiogenesis dorsal longitudinal anastomotic vessel head intersegmental vessel pericardial region trunk trunk vasculature sprouting angiogenesis whole organism anterior-posterior axis
Stage Range:	Prim-5 to Prim-25

Phenotype Detail

Acknowledgments

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