Gene
flt4
- ID
- ZDB-GENE-980526-326
- Name
- fms related receptor tyrosine kinase 4
- Symbol
- flt4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Exhibits identical protein binding activity. Involved in several processes, including motor neuron axon guidance; regulation of signal transduction; and vasculature development. Predicted to localize to integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Is expressed in several structures, including angioblastic mesenchymal cell; endothelial cell; intermediate cell mass of mesoderm; mesoderm; and vasculature. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 162 figures from 126 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1059 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary lymphedema IA | Alliance | Lymphatic malformation 1 | 153100 |
| Congenital heart defects, multiple types, 7 | 618780 | ||
| Hemangioma, capillary infantile, somatic | 602089 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013151 | Immunoglobulin-like beta-sandwich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041348 | VEGFR-2, transmembrane domain |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like beta-sandwich domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site | VEGFR-2, transmembrane domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5MD89
|
1357 | ||||||||||||||||
|
UniProtKB:A0A8M3AZL8
|
1364 | ||||||||||||||||
|
UniProtKB:A0A0R4IFS9
|
1368 | ||||||||||||||||
|
UniProtKB:A0A2R8QSE0
|
1324 |
Interactions and Pathways
No data available
Plasmids