FIGURE

Fig. S2

ID

ZDB-FIG-190822-15

Publication

Pei et al., 2018 - Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues

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Fig. S2

Mutations tested that affected hair cell development.

(A-D) Developmental timing of neuromast hair cell formation was assayed by Yopro-1 staining (A-C) or hair cell-specific antibody staining (D). Arrows point to hair cell-positive neuromasts. Mutant embryos had smaller staining area for each neuromast and fewer neuromasts, indicating an impairment in hair cell development. (E-H) Quantification of neuromast hair cell development by counting Yopro-1 positive hair cells. Compared to the control (Ctrl) siblings, homozygous (hom) mutants of sec61a1show a significant reduction in the average number of hair cells per neuromast.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eif4a1a^{la016053Tg/la016053Tg} etf1b^{la029646Tg/la029646Tg} mcm7^{la010422Tg/la010422Tg} rpa1^{la010246Tg/la010246Tg} rps20^{la029651Tg/la029651Tg} sec61a1a^{la011479Tg/la011479Tg} snrnp48^hg100/hg100 taf5^hg102/hg102
Observed In:	neuromast development neuromast hair cell posterior lateral line neuromast
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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