FIGURE

Fig. 2

ID

ZDB-FIG-190814-19

Publication

Pei et al., 2018 - Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues

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Fig. 2

Mutations causing embryonic phenotypes. a Retroviral mutations causing embryonic phenotypes. Degree of severity ranged for the early embryonic phenotypes. snapc1b mutants appeared essentially normal but they failed to inflate the swim bladder and eventually die by day 10. etf1 mutants had severe craniofacial defects, small eyes, and cardiac edema. rps20mutants were the most severely disrupted with severe growth retardation and an overall failure to thrive. b CRISPR/Cas9 mutations causing embryonic phenotypes. The mutants in heat shock family proteins hspe1 and hspa13 and small nuclear protein snrnp25 all appeared normal but failed to inflate the swim bladder and eventually die around day 10–15. snrnp48mutants had small eyes and abnormal jaw structure. taf5 mutants display craniofacial defects. β-catenin (ctnnb1) mutants have disrupted tail development, heart edemas and reduced head and eyes

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ctnnb1^hg101/hg101 etf1b^{la029646Tg/la029646Tg} hspa13^hg78/hg78 hspa13^hg79/hg79 hspe1^hg76/hg76 hspe1^hg77/hg77 rps20^{la029651Tg/la029651Tg} snapc1b^{la010158Tg/la010158Tg} snrnp25^hg99/hg99 snrnp48^hg100/hg100 taf5^hg102/hg102
Observed In:	eye head pericardium post-vent region swim bladder whole organism
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Regen Med