FIGURE

Fig. 2 S1

ID

ZDB-FIG-190723-185

Publication

Grimm et al., 2019 - Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2 S1

Z yap1-/- mutants only exhibit mild lymphatic defects in the trunk and MZ yap1-/- mutants form facial lymphatics.

( A) Trunk lymphatics of sibling and Z yap1ncv101-/- mutant at 5 dpf. The vasculature is shown in red [ Tg(kdrl:mCherry)], venous and lymphatics in green [ Tg(dab2b:EGFP)]. Scale bar: 50 μm. ( B) Heads of siblings and MZ yap1ncv101-/- mutants showing facial lymphatics including the lateral facial lymphatic (LFL), medial facial lymphatic (MFL), otolithic lymphatic vessel (OLV), branchial arch lymphatics (LAA); and developing lymphatic loop (LL). Scale bar: 50 μm. ( C) Percentage of thoracic duct (TD) segments formed across 6 somites at 5 dpf in siblings (98.17 ± 1.83, n = 18) and Z yap1ncv101-/- mutants (77.54 ± 10.14, n = 13; p=0.0269). ( D) Score of facial lymphatics in siblings (LL: 0.75 ± 0.08, n = 10) and MZ yap1ncv101-/- mutants (LL: 0.67 ± 0.11, n = 6; p=0.55 (ns)). Each point represents the vessel score for one embryo. Matrix scores for LFL, MFL and OFL between sibling and MZ yap1ncv101-/- are identical, thus not significantly different.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife