FIGURE

Fig. 6

ID

ZDB-FIG-190107-4

Publication

Blanco-Sánchez et al., 2018 - Grxcr1 Promotes Hair Bundle Development by Destabilizing the Physical Interaction between Harmonin and Sans Usher Syndrome Proteins

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Fig. 6

The Integrity of the cis-Golgi and Abundance of Ush1c and Ush1ga Are Affected in grxcr1^−/− Mutants

(A and B) Immunolabeling of GM130 in the anterior maculae of grxcr1^+/+ (A) and grxcr1^−/− (B).

(C) Quantification of GM130 signal intensity in grxcr1^+/+ (n = 29 larvae) and grxcr1^−/− (n = 29 larvae) anterior maculae.

(D and E) Immunolabeling of Ush1c in the anterior maculae of grxcr1^+/+ (D) and grxcr1^−/− larvae (E).

(F) Quantification of Ush1c signal intensity in the anterior macula of grxcr1^+/+ (n = 37 larvae) and grxcr1^−/− larvae (n = 37 larvae).

(G and H) Immunolabeling of Ush1ga in the anterior maculae of grxcr1^+/+ (G) and grxcr1^−/− larvae (H).

(I) Quantification of Ush1ga signal intensity in grxcr1^+/+ (n = 33 larvae) and grxcr1^−/− larvae (n = 36 larvae).

(J and K) Immunolabeling of Ush1g in the anterior maculae of grxcr1^+/+ (J) and grxcr1^−/− larvae (K).

(L) Quantification of Ush1g signal intensity in grxcr1^+/+ (n = 14 larvae) and grxcr1^−/− larvae (n = 15 larvae).

Data were normalized to grxcr1^+/+ and are represented as mean ± SEM. ^∗p < 0.05; 5 dpf.

Expression Data

Gene:	ush1ga
Antibodies:	Ab1-golga2 Ab1-ush1ga Ab5-ush1c
Fish:	WT grxcr1a^b1259/b1259
Anatomical Term:	hair cell anterior macula
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	grxcr1a^b1259/b1259
Observed In:	hair cell anterior macula hair cell anterior macula Golgi apparatus
Stage:	Day 5

Phenotype Detail

Acknowledgments

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