FIGURE

Fig. 3

ID

ZDB-FIG-190107-2

Publication

Blanco-Sánchez et al., 2018 - Grxcr1 Promotes Hair Bundle Development by Destabilizing the Physical Interaction between Harmonin and Sans Usher Syndrome Proteins

Other Figures

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Fig. 3

ush1c^−/− and ush1ga^−/− Mutants Have Dysmorphic Hair Bundles

(A and B) Phalloidin staining of the anterior macula in ush1c siblings (A) and ush1c^fh293/fh293 mutant larvae (B). The red arrowhead points to splayed hair bundles.

(C) Average width of hair bundles at half their height in ush1c^fh293 siblings (n = 15 larvae) and ush1c^fh293/fh293 (n = 14 larvae).

(D) Number of hair bundles splayed in ush1c^fh293 siblings (n = 15 larvae) and ush1c^fh293/fh293 (n = 14 larvae).

(E–H) Phalloidin staining of the anterior macula at in ush1ga siblings (E and G), ush1ga^b1342/b1342 (F), and ush1ga^b1240/b1240 mutant larvae (H).

(I) Average hair bundle width at half their height in ush1ga^b1342 siblings (n = 10 larvae), ush1ga^b1342/b1342 (n = 11 larvae), ush1ga^b1240 siblings (n = 28 larvae), and ush1ga^b1240/b1240 mutant larvae (n = 9 larvae).

(J) Number of hair bundles splayed in ush1ga^b1342 siblings (n = 15 larvae), ush1ga^b1342/b1342 (n = 13 larvae), ush1ga^b1240 siblings (n = 35 larvae), and ush1ga^b1240/b1240 mutant larvae (n = 14 larvae).

Data are represented as mean ± SEM. ^∗∗p < 0.01; 5 dpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ush1c^fh293/fh293 ush1ga^b1240/b1240 ush1ga^b1342/b1342
Observed In:	hair cell anterior macula
Stage:	Day 5

Phenotype Detail

Acknowledgments

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