FIGURE

Fig. 4

ID

ZDB-FIG-180828-69

Publication

Vorontsova et al., 2018 - Aqp0a Regulates Suture Stability in the Zebrafish Lens

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Fig. 4

Aqp0a is required for normal lens optics. Representiative lenses dissected from WT, aqp0a^−/−, aqp0b^−/−, or double mutant zebrafish of SL >23 mm imaged through their optical axis (equatorial orientation). Lenses imaged under brightfield (BF; [A]) and darkfield (DF; [B]) illumination reveal a clear lens for WT and aqp0b^−/− mutants, while aqp0a^−/− mutants have mild refractive changes between the nucleus and lens periphery. Double mutant lenses have a severe nuclear cataract with cortical refractive problems. (C) Optical properties of lenses were tested by focusing through the lens onto micrometer grids, which revealed poor optical properties of the aqp0a^−/− and double mutant lenses.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mipa^{ir1090/ir1090} (AB) mipb^{ir1091/ir1091} (AB) mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)
Observed In:	lens lens central region lens lens development in camera-type eye
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.