FIGURE

Fig. 5

ID

ZDB-FIG-180712-68

Publication

Kidwell et al., 2018 - Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

atoh1c is required for cerebellar granule cell fate. A-D: Reduction in the number of mature GCs in atoh1c mutant as indicated by decreased staining for cerebellin12 (B) and vglut1 (D), at 5 dpf. E-H: The majority of mutant cells expressing Tg(atoh1c::kaede) remain as a non-migrated population in the URL at 3 dpf (G, G′ compare to wild-type in E, E′) and 5 dpf (H, H′ compare to wild-type in F, F′). I-J: Upregulation of atoh1c mRNA in URL at 5 dpf in atoh1c mutant embryos (J, J′ compare to I, I′). Dorsal (A,B,C,D,E,F,G,H,I,J), ventral (A′,B′) and lateral (A”,B”,C′,D′,E′,F′,G′, H′,I′,J′) views are shown with anterior to the left. Scale bars: 50 μM.

Expression Data

Genes:	atoh1c cbln12 Kaede slc17a7a
Fish:	WT atoh1c^fh367/fh367 fh430Tg; s1999tTg atoh1c^fh367/fh367; fh430Tg; s1999tTg
Anatomical Terms:	cerebellum glutamatergic neuron corpus cerebelli corpus cerebelli cerebellar granule cell granular eminence granular eminence cerebellar granule cell hindbrain anterior margin medial caudal lobe medial caudal lobe cerebellar granule cell molecular layer corpus cerebelli parallel fiber
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atoh1c^fh367/fh367 atoh1c^fh367/fh367; fh430Tg; s1999tTg
Observed In:	cerebellar granule cell cerebellar granule cell differentiation cerebellum glutamatergic neuron corpus cerebelli corpus cerebelli cerebellar granule cell corpus cerebelli cerebellar granule cell differentiation granular eminence granular eminence cerebellar granule cell granular eminence cerebellar granule cell differentiation hindbrain anterior margin medial caudal lobe medial caudal lobe cerebellar granule cell medial caudal lobe cerebellar granule cell differentiation parallel fiber
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 438(1), Kidwell, C.U., Su, C.Y., Hibi, M., Moens, C.B., Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum, 44-56, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.