ZFIN Image: Kidwell et al., 2018, Fig. 5

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Figure Caption

Fig. 5

atoh1c is required for cerebellar granule cell fate. A-D: Reduction in the number of mature GCs in atoh1c mutant as indicated by decreased staining for cerebellin12 (B) and vglut1 (D), at 5 dpf. E-H: The majority of mutant cells expressing Tg(atoh1c::kaede) remain as a non-migrated population in the URL at 3 dpf (G, G′ compare to wild-type in E, E′) and 5 dpf (H, H′ compare to wild-type in F, F′). I-J: Upregulation of atoh1c mRNA in URL at 5 dpf in atoh1c mutant embryos (J, J′ compare to I, I′). Dorsal (A,B,C,D,E,F,G,H,I,J), ventral (A′,B′) and lateral (A”,B”,C′,D′,E′,F′,G′, H′,I′,J′) views are shown with anterior to the left. Scale bars: 50 μM.

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Acknowledgments

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Reprinted from Developmental Biology, 438(1), Kidwell, C.U., Su, C.Y., Hibi, M., Moens, C.B., Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum, 44-56, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.