FIGURE

Fig. 6

ID

ZDB-FIG-170925-14

Publication

He et al., 2017 - Insm1a Is Required for Zebrafish Posterior Lateral Line Development.

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Fig. 6

Insm1a regulates the expression of Wnt and Fgf signaling components. Expression of the Wnt and Fgf target genes lef1 (A,B), axin2 (D,E), fgf3 (G,H), fgf10a (I,J), and pea3 (K,L) in control embryos and in insm1a morphants at 30–32 hpf. (C,F) The ratio of lef1-positive cells (C) or axin2-positive cells (F) to total cells in the primordia of controls (black bars) and insm1a morphants (gray bars). Data are expressed as mean ± s.e.m. ***p < 0.001. In insm1a primordia, the expression domains of lef1 and axin2 expand, whereas fgf3 and fgf10a expression is normal but pea3 is reduced. The primordium is outlined with a dotted line, and the anterior is to the left. Scale bar: 10 μm.

Expression Data

Genes:	axin2 etv4 lef1
Fish:	WT WT + MO4-tp53 + MO5-insm1a
Knockdown Reagents:	MO4-tp53 MO5-insm1a
Anatomical Term:	posterior lateral line primordium
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO4-tp53 + MO5-insm1a
Knockdown Reagents:	MO4-tp53 MO5-insm1a
Observed In:	posterior lateral line primordium regulation of canonical Wnt signaling pathway
Stage:	Prim-15

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.