Gene
lef1
- ID
- ZDB-GENE-990714-26
- Name
- lymphoid enhancer-binding factor 1
- Symbol
- lef1 Nomenclature History
- Previous Names
-
- etID310027.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Exhibits sequence-specific DNA binding activity. Involved in several processes, including animal organ development; fin development; and regulation of gene expression. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in ovarian cancer. Is expressed in several structures, including midbrain hindbrain boundary neural rod; nervous system; neural crest; pleuroperitoneal region; and trunk. Orthologous to human LEF1 (lymphoid enhancer binding factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 139 figures from 99 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 31 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| anxiety disorder | lef1zd11/zd11 | standard conditions | Xie et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009071 | High mobility group box domain |
| Domain | IPR013558 | CTNNB1 binding, N-teminal |
| Family | IPR024940 | Transcription factor TCF/LEF |
| Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
| Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
Domain Details Per Protein
| Protein | Length | Catenin binding domain superfamily | CTNNB1 binding, N-teminal | High mobility group box domain | High mobility group box domain superfamily | Transcription factor TCF/LEF |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9W7C0
|
365 |
Interactions and Pathways
Plasmids