Gene
axin2
- ID
- ZDB-GENE-000403-2
- Name
- axin 2 (conductin, axil)
- Symbol
- axin2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Involved in dorsal/ventral axis specification and negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Predicted to localize to cytoplasm. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in colorectal cancer and endometrial adenocarcinoma. Is expressed in several structures, including anterior neural keel; digestive system; marginal blastomere; nervous system; and pharyngeal arch. Orthologous to human AXIN2 (axin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 95 figures from 73 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:3818167 (27 images)
- eu48 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Oligodontia-colorectal cancer syndrome | 608615 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB + MO1-axin2 | standard conditions | Zhu et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001158 | DIX domain |
| Domain | IPR014936 | Axin beta-catenin binding |
| Domain | IPR016137 | RGS domain |
| Domain | IPR032101 | Axin-1/2, tankyrase-binding domain |
| Family | IPR043581 | Axin-like |
| Homologous_superfamily | IPR024066 | RGS, subdomain 1/3 |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036305 | RGS domain superfamily |
| Homologous_superfamily | IPR038207 | DIX domain superfamily |
| Homologous_superfamily | IPR044926 | RGS, subdomain 2 |
Domain Details Per Protein
| Protein | Length | Axin-1/2, tankyrase-binding domain | Axin beta-catenin binding | Axin-like | DIX domain | DIX domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 1/3 | RGS, subdomain 2 | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:P57095
|
812 |
Interactions and Pathways
No data available
Plasmids