FIGURE

Fig. 2

ID

ZDB-FIG-170912-21

Publication

Lamont et al., 2016 - The LIM-homeodomain transcription factor Islet2a promotes angioblast migration

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Isl2 modulates vein cell marker expression. Compared to wild type controls (A,C,E,G), expression of the venous markers flt4 (B) and mrc1 (D) is reduced in the trunk of isl2a morphants at 24 hpf, while there is no obvious change in the expression of arterial markers notch3 (F) and ephrinb2 (H). (A′-H′) are cross sections of embryos in A-H. (I) There is a 41% reduction in flt4 expression by qPCR (p<0.0001 by student's t-test) in isl2a morphants. Scale bars represent 200 µm in A-H and 30 µm in cross-sections A′-H′. Abbreviations: posterior cardinal vein (pcv), dorsal aorta (da), neural tube (nt) and pronephric ducts (pd).

Expression Data

Genes:	efnb2a flt4 mrc1a notch3
Fish:	TL TL + MO4-isl2a + MO5-isl2a
Knockdown Reagents:	MO4-isl2a MO5-isl2a
Anatomical Terms:	dorsal aorta neural tube posterior cardinal vein pronephric duct whole organism
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO4-isl2a + MO5-isl2a
Knockdown Reagents:	MO4-isl2a MO5-isl2a
Observed In:	dorsal aorta posterior cardinal vein whole organism
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 414, Lamont, R.E., Wu, C.Y., Ryu, J.R., Vu, W., Davari, P., Sobering, R.E., Kennedy, R.M., Munsie, N.M., Childs, S.J., The LIM-homeodomain transcription factor Islet2a promotes angioblast migration, 181-92, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.