FIGURE

Fig. 3

ID

ZDB-FIG-161122-4

Publication

Bhattarai et al., 2016 - IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-?42 Aggregation in Adult Zebrafish Brain

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Fig. 3

A?42-Dependent Stem Cell Proliferation Requires Microglial Activity

(A?D) L-plastin and HuC/D in control peptide/control liposome (A), control peptide/clodronate liposome (B), TR-A?42/control liposome (C), and TR-A?42/clodronate liposome (D) injections. Right panels: green channel.

(E) S100? and PCNA in brains injected with the four combinations in (A?D).

(F) Quantification of the number of L-plastin-positive cells.

(F') Quantification of proliferating NSPCs.

(G) Examples of ramified and round/ameoboid L-plastin-positive cells. Round cells are around amyloid (green, 4G8 staining).

(H) Quantification for the average number of PCNA-positive cells in clodronate-injected brains.

Scale bars, 50 ?m. Data are represented as mean � SD; n = 4 fish. ^?p < 0.05; ^???p < 0.001; n.s., not significant. See also Tables S1 and S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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