FIGURE

Fig. 4

ID

ZDB-FIG-160826-14

Publication

Ji et al., 2016 - Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs

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Fig. 4

Malformations of the anterior segment of the eye in Pitx2HD mutant embryos. (A-C) Cryosections of the eye from 5 dpf wild-type (A), pitx2HD^sny7/sny7 (B) and pitx2c^sny3/sny3 (C) fish stained with crystal violet. AC=anterior chamber; ICA=iridocorneal angle. Scale bars=50 µm. (A′-C′) Enlarged view of box 1 in A-C showing anterior segment structures. In pitx2HD mutants (B′), the anterior chamber was reduced and the iridocorneal angle (arrow) was malformed. Scale bars=10 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pitx2^sny3/sny3 (AB/TU) pitx2^sny7/sny7 (AB/TU)
Observed In:	anterior segment eye aqueous humor camera-type eye morphogenesis cornea eye iris
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 416(1), Ji, Y., Buel, S.M., Amack, J.D., Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs, 69-81, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.