FIGURE

Fig. 3

ID

ZDB-FIG-160826-13

Publication

Ji et al., 2016 - Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs

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Fig. 3

Pitx2HD mutants grow to adulthood and develop eye defects. (A) Normal gross appearance of wild-type, pitx2HD^sny7/sny7 and pitx2c^sny3/sny3 fish at 5 dpf. (B) Homozygous pitx2HD mutants reached adulthood, but were smaller than heterozygous siblings and had malformed eyes (arrow). Adult homozygous pitx2c mutants were indistinguishable from wild-type siblings. (C) Eye and craniofacial phenotypes in adult fish. Ocular defects of the iris and cornea (arrow) were observed in pitx2HD mutants, but not pitx2c mutants.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pitx2^sny3/sny3 (AB/TU) pitx2^sny7/sny7 (AB/TU) pitx2^sny3/+ (AB/TU) pitx2^sny7/+ (AB/TU)
Observed In:	camera-type eye morphogenesis cornea eye iris whole organism
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 416(1), Ji, Y., Buel, S.M., Amack, J.D., Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs, 69-81, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.