FIGURE

Fig. 5

ID

ZDB-FIG-160818-5

Publication

George et al., 2016 - Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors

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Fig. 5

The distribution of PI(3,5)P₂ positive late endosomal compartments is the same in wild type (WT) and nrc^a14 cells. A; The PI(3,5)P₂ probe ML1NX2 localizes to small, punctate structures in the inner segments of WT and nrc^a14 cone photoreceptors in 5 days post-fertilization Tg(TαCP : mCherry-ML1NX2) transgenic larvae. B: Some PI(3,5)P₂ puncta overlap with LC3 positive puncta in nrc^a14 but not WT cones, agreeing with the decrease in acidic LC3-positive structures observed in Fig. 2. C: The PI(3,5)P₂ partially overlaps with Rab7 puncta in both WT and nrc^a14 cone photoreceptors, but is not found on abnormal Rab7 structures in nrc^a14 cones. Scale bar = 2 µm in all images.

Expression Data

Genes:	GFP mCherry
Fish:	synj1^a14/a14; w137Tg; w189Tg synj1^a14/a14; w138Tg; w189Tg
Anatomical Terms:	retinal cone cell retinal cone cell autophagosome retinal cone cell cytoplasm
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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