FIGURE

Fig. 7

ID

ZDB-FIG-151221-8

Publication

Chua et al., 2015 - Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

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Fig. 7

Accumulation of mutant p53 protein in tumors of p53^M214K/M214K fish. Adult p53^M214K/M214K zebrafish that were observed to have developed tumors in the eye and trunk were sacrificed, fixed and embedded in paraffin for histological analysis with the p53-5.1 hybridoma supernatant. The sections were counterstained with hematoxylin and imaged under brightfield. (a) Normal eye from a p53^M214K/M214K fish ( × 10 magnification). (b) Tumor in the eye of a p53^M214K/M214K fish ( × 10 magnification). (c) Tumor in the eye of a p53^M214K/M214K fish ( × 40 magnification). (d) Tumor in the trunk of a p53^M214K/M214K fish ( × 40 magnification). P, pigmentation of eye lens.

Expression Data

Gene:	tp53
Antibody:	Ab2-tp53
Fish:	tp53^zdf1/zdf1
Anatomical Terms:	eye neoplasm trunk soft tissue tumor
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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