FIGURE

Fig. 6

ID

ZDB-FIG-151221-7

Publication

Chua et al., 2015 - Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

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Fig. 6

mdm2^-/-; p53^M214K/M214K adult zebrafish accumulate mutant p53 protein in most tissues. Five-month-old mdm2^-/-; p53^M214K/M214K, mdm4^-/-; p53^M214K/M214K and p53^M214K/M214K adult zebrafish were sacrificed, fixed and embedded in paraffin for histological analysis with the p53-5.1 hybridoma supernatant. The sections were counterstained with hematoxylin and imaged under brightfield at × 40 magnification. E, epidermis; CE, columnar epithelium; CSM, circular smooth muscle; T, renal tubule; H, hepatocytes; S, sinusoid

Expression Data

Gene:	tp53
Antibody:	Ab2-tp53
Fish:	tp53^zdf1/zdf1 tp53^zdf1/zdf1; mdm2^sq25/sq25 tp53^zdf1/zdf1; mdm2^sq26/sq26 tp53^zdf1/zdf1; mdm2^sq27/sq27 tp53^zdf1/zdf1; mdm4^sq29/sq29 tp53^zdf1/zdf1; mdm4^sq30/sq30 tp53^zdf1/zdf1; mdm4^sq31/sq31
Anatomical Terms:	integument intestinal epithelium kidney liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1; mdm2^sq25/sq25 tp53^zdf1/zdf1; mdm2^sq26/sq26 tp53^zdf1/zdf1; mdm2^sq27/sq27
Observed In:	integument intestinal epithelium kidney liver
Stage:	Adult

Phenotype Detail

Acknowledgments

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