Gene

tp53

ID

ZDB-GENE-990415-270

Name

tumor protein p53

Symbol

tp53 Nomenclature History

Previous Names

p53 (1)
brp53
drp53
etID22686.5 (1)
fb40d06
wu:fb40d06 (1)
zgc:111919

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of nucleobase-containing compound metabolic process; and signal transduction by p53 class mediator. Localizes to chromatin. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; and cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Orthologous to human TP53 (tumor protein p53).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

227 figures from 186 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:111919 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 55 figures from 40 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tp53 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
adrenocortical carcinoma	Alliance	{Adrenocortical carcinoma, pediatric}	202300
breast cancer	Alliance	Breast cancer, somatic	114480
choroid plexus papilloma	Alliance	{Choroid plexus papilloma}	260500
colorectal cancer	Alliance	{Colorectal cancer}	114500
hepatocellular carcinoma	Alliance	Hepatocellular carcinoma, somatic	114550
Li-Fraumeni syndrome 1	Alliance	Li-Fraumeni syndrome	151623
nasopharynx carcinoma	Alliance	Nasopharyngeal carcinoma, somatic	607107
osteosarcoma	Alliance	{Osteosarcoma}	259500
pancreatic carcinoma	Alliance	Pancreatic cancer, somatic	260350
		Bone marrow failure syndrome 5	618165
		{Basal cell carcinoma 7}	614740
		{Glioma susceptibility 1}	137800

Associated With tp53 Via Experimental Models

Human Disease	Fish	Conditions	Citations
malignant peripheral nerve sheath tumor	tp53^zdf1/zdf1	standard conditions	Nissim et al., 2019
cancer	tp53^fb105/fb105	standard conditions	Ignatius et al., 2018
angiosarcoma	tp53^fb105/fb105	standard conditions	Ignatius et al., 2018
Li-Fraumeni syndrome	tp53^zy7/+ (AB)	standard conditions	Parant et al., 2010
Li-Fraumeni syndrome	tp53^zy7/zy7 (AB)	standard conditions	Parant et al., 2010
aggressive NK-cell leukemia	tp53^fb105/fb105	standard conditions	Ignatius et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010991	p53, tetramerisation domain
Domain	IPR011615	p53, DNA-binding domain
Family	IPR002117	p53 tumour suppressor family
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR036674	p53-like tetramerisation domain superfamily

Domain Details Per Protein

Protein	Length	p53, DNA-binding domain	p53-like tetramerisation domain superfamily	p53-like transcription factor, DNA-binding domain superfamily	p53/RUNT-type transcription factor, DNA-binding domain superfamily	p53, tetramerisation domain	p53 tumour suppressor family
UniProtKB:A0A8M2BCD8 InterPro	370
UniProtKB:A0A8M2BCE6 InterPro	257
UniProtKB:B0R0M3 InterPro	369
UniProtKB:P79734 InterPro PDB	373
UniProtKB:A0A0B4VFS7 InterPro	261
UniProtKB:G1K2L5 InterPro PDB	374

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tp53-201 (1) Ensembl	Ensembl	2,211 nt	Select Tool ZFIN BLAST
mRNA	tp53-203 (1) Ensembl	Ensembl	2,204 nt	Select Tool
mRNA	tp53-206 (1) Ensembl	Ensembl	2,208 nt	Select Tool ZFIN BLAST
mRNA	tp53-207 (1) Ensembl	Ensembl	1,195 nt	Select Tool ZFIN BLAST
mRNA	tp53-208 (1) Ensembl	Ensembl	1,956 nt	Select Tool ZFIN BLAST
ncRNA	tp53-002 (1) Ensembl	Ensembl	802 nt	Select Tool
ncRNA	tp53-003 (1) Ensembl	Ensembl	579 nt	Select Tool
ncRNA	tp53-004 (1) Ensembl	Ensembl	748 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tp53	monoclonal	tp53		Mouse	IHC WB		3
Ab10-tp53	monoclonal	tp53		Mouse	IHC WB		9
Ab11-tp53	monoclonal	tp53	IgG	Mouse	IHC WB	Abcam plc	15
Ab2-tp53	monoclonal	tp53	IgG1	Mouse	IHC WB		3
Ab6-tp53	monoclonal	tp53		Mouse	WB		2
Ab7-tp53	polyclonal	tp53		Rabbit	WB	AnaSpec	9
Ab3-tp53	monoclonal	tp53	IgG1	Mouse	WB		6
Ab4-tp53	polyclonal	tp53		Rabbit			1
Ab9-tp53	polyclonal	tp53		Rabbit			1

Plasmids

Addgene:MiniCoopR U6:gRNA p53, mitfa:Cas9

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations