Gene

tp53

ID

ZDB-GENE-990415-270

Name

tumor protein p53

Symbol

tp53 Nomenclature History

Previous Names

p53 (1)
brp53
drp53
etID22686.5 (1)
fb40d06
wu:fb40d06 (1)
zgc:111919

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification and transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; head; hematopoietic system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; cancer; and malignant peripheral nerve sheath tumor. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

230 figures from 189 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:111919 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 55 figures from 40 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tp53 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
adrenocortical carcinoma	Alliance	{Adrenocortical carcinoma, pediatric}	202300
breast cancer	Alliance	Breast cancer, somatic	114480
choroid plexus papilloma	Alliance	{Choroid plexus papilloma}	260500
colorectal cancer	Alliance	{Colorectal cancer}	114500
hepatocellular carcinoma	Alliance	Hepatocellular carcinoma, somatic	114550
Li-Fraumeni syndrome 1	Alliance	Li-Fraumeni syndrome	151623
nasopharynx carcinoma	Alliance	Nasopharyngeal carcinoma, somatic	607107
osteosarcoma	Alliance	{Osteosarcoma}	259500
pancreatic carcinoma	Alliance	Pancreatic cancer, somatic	260350
		Bone marrow failure syndrome 5	618165
		{Basal cell carcinoma 7}	614740
		{Glioma susceptibility 1}	137800

Associated With tp53 Via Experimental Models

Human Disease	Fish	Conditions	Citations
malignant peripheral nerve sheath tumor	tp53^zdf1/zdf1	standard conditions	Nissim et al., 2019
cancer	tp53^fb105/fb105	standard conditions	Ignatius et al., 2018
angiosarcoma	tp53^fb105/fb105	standard conditions	Ignatius et al., 2018
Li-Fraumeni syndrome	tp53^zy7/+ (AB)	standard conditions	Parant et al., 2010
Li-Fraumeni syndrome	tp53^zy7/zy7 (AB)	standard conditions	Parant et al., 2010
aggressive NK-cell leukemia	tp53^fb105/fb105	standard conditions	Ignatius et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010991	p53, tetramerisation domain
Domain	IPR011615	p53, DNA-binding domain
Family	IPR002117	p53 tumour suppressor family
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR036674	p53-like tetramerisation domain superfamily

Domain Details Per Protein

Protein	Length	p53, DNA-binding domain	p53-like tetramerisation domain superfamily	p53-like transcription factor, DNA-binding domain superfamily	p53/RUNT-type transcription factor, DNA-binding domain superfamily	p53, tetramerisation domain	p53 tumour suppressor family
UniProtKB:A0A8M2BCD8 InterPro	370
UniProtKB:A0A8M2BCE6 InterPro	257
UniProtKB:B0R0M3 InterPro	369
UniProtKB:P79734 InterPro PDB	373
UniProtKB:A0A0B4VFS7 InterPro	261
UniProtKB:G1K2L5 InterPro PDB	374

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tp53-201 (1) Ensembl	Ensembl	2,211 nt	Select Tool ZFIN BLAST
mRNA	tp53-203 (1) Ensembl	Ensembl	2,204 nt	Select Tool ZFIN BLAST
mRNA	tp53-206 (1) Ensembl	Ensembl	2,208 nt	Select Tool ZFIN BLAST
mRNA	tp53-207 (1) Ensembl	Ensembl	1,195 nt	Select Tool ZFIN BLAST
mRNA	tp53-208 (1) Ensembl	Ensembl	1,956 nt	Select Tool ZFIN BLAST
ncRNA	tp53-002 (1) Ensembl	Ensembl	802 nt	Select Tool ZFIN BLAST
ncRNA	tp53-003 (1) Ensembl	Ensembl	579 nt	Select Tool ZFIN BLAST
ncRNA	tp53-004 (1) Ensembl	Ensembl	748 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tp53	monoclonal	tp53		Mouse	IHC WB		4
Ab10-tp53	monoclonal	tp53		Mouse	IHC WB		9
Ab11-tp53	monoclonal	tp53	IgG	Mouse	IHC WB	Abcam plc	15
Ab2-tp53	monoclonal	tp53	IgG1	Mouse	IHC WB		3
Ab6-tp53	monoclonal	tp53		Mouse	WB		2
Ab7-tp53	polyclonal	tp53		Rabbit	WB	AnaSpec	9
Ab3-tp53	monoclonal	tp53	IgG1	Mouse	WB		6
Ab4-tp53	polyclonal	tp53		Rabbit			1
Ab9-tp53	polyclonal	tp53		Rabbit			1

Plasmids

Addgene:MiniCoopR U6:gRNA p53, mitfa:Cas9

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations