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Fig. S3

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ZDB-FIG-150416-31

Publication

Wen et al., 2015 - Sox4 regulates choroid fissure closure by limiting hedgehog signaling during ocular morphogenesis

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Fig. S3

Sox4 knockdown causes ectopic proliferation in the ganglion cell layer. (A-B) Clusters of PNCA- and PH3-positive cells were observed in the GCL of sox4 morphant retinas at 72 hpf (B, dashed line), whereas in control morphants proliferative cells were only observed in the CMZ. (C-D) Pax6a was expressed in the GCL and inner half of the INL in control and sox4 morphants at 72 hpf; however a dense clump of extra cells in the GCL of sox4 morphants was pax6a-negative (D, dashed line). (E-F) Immunostaining of control and sox4 morphant retinas with the ganglion cell marker Zn-8. Clusters of Zn-8-negative cells were present in the GCL of sox4 morphants (F, dashed line). D, dorsal; V, ventral; L, lens; CMZ, ciliary marginal zone; GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; ON, optic nerve.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 399(1), Wen, W., Pillai-Kastoori, L., Wilson, S.G., Morris, A.C., Sox4 regulates choroid fissure closure by limiting hedgehog signaling during ocular morphogenesis, 139-53, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.