FIGURE

Fig. 5

ID

ZDB-FIG-150331-19

Publication

Shao et al., 2009 - Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos

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Fig. 5

Interaction between Dscr5 and the PCP pathway in CE movements. (A) Rescue of CE movements by dshΔDIX in dscr5 morphants. Summary of three independent experiments of phenotypic analysis at 27 hpf with total numbers indicated at the top. (B-F) Inhibition of the JNK pathway and dscr5 knockdown enhances CE defects. (B-E) Control (B) and injected (C-E) embryos at the eight-somite stage simultaneously hybridized with myoD and dlx3 probes. Dorsoanterior view of dlx3 expression pattern. myoD expression pattern was used to control the stage of injected embryos and was not shown. (F) Summary of the phenotypes at 27 hpf. Numbers at the top represent total embryos scored from four independent experiments. (G) Knockdown of dscr5 by MO1 or MO3 inhibits JNK activation. The AP1-luciferase reporter assay was performed in triplicate (P<0.03, Student′s t-test). Error bars indicate standard deviation.

Expression Data

Gene:	dlx3b
Fish:	WT WT + MO1-pigp
Knockdown Reagent:	MO1-pigp
Anatomical Term:	neural plate anatomical boundary
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-pigp WT + MO3-pigp
Knockdown Reagents:	MO1-pigp MO3-pigp
Observed In:	JNK cascade
Stage:	Shield

Phenotype Detail

Acknowledgments

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