JNK cascade

Term ID

GO:0007254

Synonyms

• c-Jun N-terminal kinase cascade
• JNK1 cascade
• JNK2 cascade
• JNK3 cascade
• MAPK10 cascade
• MAPK8 cascade
• MAPK9 cascade
• SAPK cascade
• stress-activated protein kinase cascade

Definition

A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. (3)

References

• Reactome:R-HSA-450321

Ontology

GO: Biological Process    QuickGO    AmiGO