Search Ontology:
GO: Biological Process
JNK cascade
- Term ID
- GO:0007254
- Synonyms
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- c-Jun N-terminal kinase cascade
- JNK1 cascade
- JNK2 cascade
- JNK3 cascade
- MAPK10 cascade
- MAPK8 cascade
- MAPK9 cascade
- SAPK cascade
- stress-activated protein kinase cascade
- Definition
- A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. (3)
- References
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- Reactome:R-HSA-450321
- Ontology
- GO: Biological Process QuickGO AmiGO
- has parts
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- is a type of
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- negatively regulated by
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- positively regulated by
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- regulated by
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Phenotype
Phenotype caused by Genes