FIGURE

Fig. 6

ID

ZDB-FIG-150309-11

Publication

Superina et al., 2014 - Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry

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Fig. 6

Canonical Wnt signaling is upregulated in MZjek;. (A–F) Whole-mount in situ hybridization (WISH) for dorsal organizer genes goosecoid (A,B; gsc; N=26,23) and chordin (C,D; chd; N=20,21), and ventral gene vox (E,F; N=15,18) at shield stage. Dorsal (D) and Ventral (V) orientation indicated in panel A. Embryos are viewed from the animal pole with dorsal to the right. (G–L) WISH of axin2 (G,H; N=12,8), sp5 (I,J; N=18,11), and sp5l (K,L; N=9,8) at 12 SS. Gene expression appears to be most dramatically upregulated in the tailbud (arrowheads). Anterior (A) and Posterior (P) extents are as indicated in panel G.

Expression Data

Genes:	axin2 chrd gsc sp5a sp5l vox
Fish:	WT ugdh^m310/m310
Anatomical Terms:	anatomical structure shield tail bud whole organism ventral region
Stage Range:	Shield to 10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ugdh^m310/m310
Observed In:	canonical Wnt signaling pathway
Stage Range:	Shield to 10-13 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 387(2), Superina, S., Borovina, A., and Ciruna, B., Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry, 154-166, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.