FIGURE

Fig. 3

ID

ZDB-FIG-150205-3

Publication

van der Vaart et al., 2014 - The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

dram1 Expression during Mycobacterial Infection Is Independent of p53 but Dependent on NF-κB

(A-C) Expression levels of dram1 were determined by qPCR for (A) wild-type, p53^-/-, and myd88^-/- embryos 4 days after infection with Mm, relative to mock-injected controls; (B) wild-type and p53^-/- embryos at 5 dpf after 24 hr of treatment with roscovitine, relative to untreated controls (see also Figure S3); and (C) 1 dpf embryos at 2 hpi with LPS, relative to their respective PBS-injected controls (left panel: wild-type embryos with or without NAI treatment [4 hr total, including 2 hr pretreatment]; middle panel: myd88^-/- embryos; right panel: p53^-/- embryos).

(D) Expression levels of saa were determined by qPCR under the same conditions as those described for (C).

All graphs show data (mean ± SEM) from three biological replicates with n = 20 embryos pooled per replicate. See also Figures S2 and S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Host Microbe