FIGURE

Fig. 4

ID

ZDB-FIG-140702-31

Publication

van der Vaart et al., 2014 - The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

Other Figures

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Fig. 4

DRAM1 Colocalizes with Mtb and Is Regulated by MYD88-NF-κB Signaling in Human Primary Macrophages

(A–C) The effect of NAI treatment on expression of (A) DRAM1, (B) SQSTM1, and (C) IL1B in M1 and M2 in the presence or absence of Mtb was determined by qPCR, relative to uninfected controls. All graphs show data (mean ± SEM) from three biological replicates.

(D) Expression of DRAM1 in M1 and M2 transfected with siCTRL or siMYD88 with and without Mtb infection. All graphs show data (mean ± SEM) from three biological replicates.

(E and F) Immunohistochemistry for (E) DRAM1 (green) or (F) LC3 (green) performed on M1 and M2 at 72 hpi with Mtb (red); Hoechst staining (blue) was used to outline the nuclei and cell boundaries. See also Figure S4.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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