FIGURE

Fig. 7

ID

ZDB-FIG-140414-19

Publication

Johnson et al., 2014 - Kif11 dependent cell cycle progression in radial glial cells is required for proper neurogenesis in the zebrafish neural tube

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Fig. 7

Kif11 function is most required during two distinct periods for proper cell division. (A) Schematic illustrating time of exposure to S-trityl-⌊-cysteine (STLC) or vehicle control (dimethyl sulfoxide) and duration of treatment between groups. (B–G) Lateral views of post-treatment embryos labeled for radial glia (Gfap), Ph3 and AT. (H) In all test groups, there were significantly more Gfap+/Ph3+ and Gfap-/Ph3+ cells in STLC treated embryos (E–G) compared with their controls (B–D) at 5–30 hpf, 10–30 hpf, 15–30 hpf, 20–30 hpf, and 25–30 hpf. Error bars delineate the standard error of the mean. Asterisks indicate a statistical significance (t-test, two tailed, assuming equal variances, p<0.05).

Expression Data

Antibody:	zrf-1
Fish:	WT
Condition:	chemical treatment: pharmaceutical
Anatomical Term:	radial glial cell
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 387(1), Johnson, K., Moriarty, C., Tania, N., Ortman, A., Dipietrantonio, K., Edens, B., Eisenman, J., Ok, D., Krikorian, S., Barragan, J., Golé, C., and Barresi, M.J., Kif11 dependent cell cycle progression in radial glial cells is required for proper neurogenesis in the zebrafish neural tube, 73-92, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.