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Fig. S1

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ZDB-FIG-130426-11

Publication

Choe et al., 2013 - Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation

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Fig. S1

Wnt signaling in pouch, CB cartilage, and neural crest development, related to Figure 3.

(A-L) Alcama immunohistochemistry (A-F) and Alcian Blue staining (G-L) show no pouch or CB cartilage defects upon PE-specific inhibition of nuclear-β-catenin signaling in nkx2.3:Gal4VP16; UAS:DN-Tcf7l2 embryos (A and G) or in control embryos incubated in 6% DMSO from 18-26 hpf (E and K). In contrast, severe pouch and CB defects were observed in wnt4a-MO (B and H), fzd8a-MO-II (C and I), and fzd8a-MO-injected wnt11r; wnt4a double mutants (D and J), as well as embryos incubated in 300 μM of the Rac inhibitor NSC23766 from 18-26 hpf (F and L). Arrows indicate fused or malformed CBs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 24(3), Choe, C.P., Collazo, A., Trinh, L.A., Pan, L., Moens, C.B., and Crump, J.G., Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation, 296-309, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell