FIGURE

Fig. 3

ID

ZDB-FIG-130123-56

Publication

Schweitzer et al., 2013 - Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism

Other Figures

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Fig. 3

Lateral positioning of longitudinal axons derived from otpb- and hypocretin-positive neurons is altered in ast homozygous mutants. Dorsal views of hindbrain confocal z-projections of otpb:gfp;hcrt:tdtomato double transgenic 72 hpf embryos. (A-F) In ast/ast embryos longitudinal projections of otpb:gfp (D,F; arrows in D) and hcrt:tdtomato (E,F; arrowheads in E) axons are shifted towards the midline compared with ast/+ siblings. (G) Quantification of the distance between otpb:gfp and hcrt:tdtomato HTS axons at the anterior-posterior level of Mauthner neurons, and of the distance between Mauthner neurons. ^***P<0.0001; n.s., not significant. Scale bar in A for A-F: 50 μm.

Expression Data

Genes:	EGFP Tomato
Fish:	robo2^ti272z/+; m1163Tg; zc49Tg robo2^{ti272z/ti272z}; m1163Tg; zc49Tg
Anatomical Terms:	diencephalic nucleus axon hypocretin-secreting neuron axon
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	robo2^{ti272z/ti272z}; m1163Tg; zc49Tg
Observed In:	diencephalic nucleus axon hindbrain medial region hypocretin-secreting neuron axon
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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