FIGURE

Fig. 4

ID

ZDB-FIG-120601-75

Publication

van der Velden et al., 2012 - The Polycomb group protein Ring1b is essential for pectoral fin development

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Fig. 4

LPM patterning and the RA-signaling response in ring1b mutants. (A-L) Double in situ hybridization for nkx2.5 in red and tbx5 (A-D), dhrs3 (E-H) and hoxb5b (I-L) in blue at 10 ss and 15 ss shows similar staining patterns in wild-type and ring1b mutants. Arrowheads indicate staining at the pectoral fin mesenchyme. (M-X) Dorsal views of embryos stained for the RA targets dhrs3 (M-P), hoxb5b (Q-T) and meis3 (U-X) at 20 ss and 32 hpf. Expression of hoxb5b and meis3 is normal in the ring1b LPM at 20 ss and 32 hpf, whereas dhrs3 expression is upregulated in the ring1b LPM at 32 hpf (P). Arrowheads indicate staining at the fin bud region.

Expression Data

Genes:	dhrs3a hoxb5b meis3 nkx2.5 tbx5a
Fish:	WT rnf2^ibl30/ibl30 rnf2^ibl31/ibl31
Anatomical Terms:	heart primordium lateral plate mesoderm mesoderm pectoral fin bud pectoral fin bud pectoral fin field
Stage Range:	10-13 somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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