FIGURE

Fig. 3

ID

ZDB-FIG-111026-3

Publication

Smith et al., 2011 - Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish

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Fig. 3

Dose-dependent effect of Bmpr1a on the expression of laterality genes.

In situ hybridisation at 18-somites for spaw (in LPM) and no tail (ntl) (in midline) (A–C), lefty1 at 23-somites (heart field and midline) (D–F) and pitx2 at 23-somites (in LPM) (G–I). (A,D,G) Embryos selected for normal ventral tail fin or C1 dorsalization (genotypes: bmpr1aa +/+ or +/- bmpr1ab +/+ or +/- or -/-). (B,E,H) Embryos selected for C3 dorsalization (genotype bmpr1aa-/-;bmp1ab+/-). (C,F,I) Embryos selected for C4 dorsalization (genotype bmpr1aa-/-;bmpr1ab-/-). All embryos are shown as dorsal views with anterior to the top and left to the left. Number of embryos examined is presented in Table 2.

Expression Data

Genes:	lft1 pitx2 spaw tbxta
Fish:	WT bmpr1aa^hu4087/+; bmpr1ab^sa28/+ bmpr1aa^{hu4087/hu4087}; bmpr1ab^sa28/+ bmpr1aa^{hu4087/hu4087}; bmpr1ab^sa28/sa28
Anatomical Terms:	heart primordium left side heart primordium right side lateral plate mesoderm left side lateral plate mesoderm right side notochord notochord posterior region posterior lateral plate mesoderm posterior lateral plate mesoderm left side posterior lateral plate mesoderm right side tail bud
Stage Range:	14-19 somites to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmpr1aa^{hu4087/hu4087}; bmpr1ab^sa28/sa28
Observed In:	heart rudiment
Stage:	20-25 somites

Phenotype Detail

Acknowledgments

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