Gene
spaw
- ID
- ZDB-GENE-030219-1
- Name
- southpaw
- Symbol
- spaw Nomenclature History
- Previous Names
-
- ndr3 (2)
- unm s457
- unm t30973
- unm_s457
- unm_t30973
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity and type I activin receptor binding activity. Involved in determination of left/right symmetry; embryonic heart tube left/right pattern formation; and regulation of BMP signaling pathway involved in heart jogging. Predicted to localize to extracellular space. Used to study anxiety disorder. Is expressed in anterior neural rod; cardiovascular system; diencephalon; mesoderm; and tail bud.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 182 figures from 143 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 21 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| anxiety disorder | zf105Tg/zf105Tg + MO1-spaw | standard conditions | Facchin et al., 2015 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZZT5
|
404 |
Interactions and Pathways
No data available
Plasmids
No data available