FIGURE

Fig. 4

ID

ZDB-FIG-111026-4

Publication

Smith et al., 2011 - Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish

Other Figures

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Fig. 4

Rescue of Bmp-related cardiac laterality defects by Nodal beads.

In situ hybridisation for myl7 to highlight the position of the linear heart tube at 30 hpf. Tg(hsp70l:nog3) embryos with no heat-shock (A,D) or heat-shocked at 16 hpf (B,E). Beads (blue) preincubated with recombinant Nodal protein placed in the right ALPM of non-heat-shocked (D) or heat-shocked (E) Tg(hsp70l:nog3) embryos at 17–18 hpf. Control siblings (G,J) or MZbmpr1aa mutant embryos (H,K). Beads (blue) preincubated with Nodal protein placed in the right ALPM of siblings (J) or MZbmpr1aa mutant embryos (K). Position of the inflow pole of the linear heart tube was determined for embryos without a Nodal bead (C) and for embryos in which a Nodal bead was placed on the right side (F). Embryos are shown as dorsal views with anterior to the top and left to the left.

Expression Data

Gene:	myl7
Fish:	bmpr1aa^{hu4087/hu4087} fr14Tg
Condition:	heat shock
Anatomical Term:	heart tube
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmpr1aa^{hu4087/hu4087} fr14Tg
Condition:	heat shock
Observed In:	heart looping heart tube whole organism central region
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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