FIGURE

Fig. 6

ID

ZDB-FIG-090804-33

Publication

Tao et al., 2009 - The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling

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Fig. 6

Multiple subunits of the Integrator complex regulate primitive hematopoiesis. (A-I) Whole-mount in situ hybridization to detect scl (A,B,D,E,G,H) and gata1 (C,F,I) expression in embryo injected with control morpholinos (A-C), ints11 splice-junction morpholinos (S MO, D-F) and ints9 splice-junction morpholinos (G-I). Black arrowhead indicates the anterior limit of scl expression in the ICM. The ints9 and ints11 morphants show substantially reduced scl and gata1 expression in comparison to control morphants. (J,K) Histograms showing the percentage of injected embryos with wild-type (blue) or reduced (magenta) scl (J) and gata1 (K) expression levels. Scale bars: 50 μm in A,J; 250 μm in C,K.

Expression Data

Genes:	gata1a tal1
Fish:	WT WT + MO1-ints9 WT + MO2-ints11
Knockdown Reagents:	MO1-ints9 MO2-ints11
Anatomical Terms:	intermediate cell mass of mesoderm lateral plate mesoderm
Stage Range:	5-9 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-ints9 WT + MO2-ints11
Knockdown Reagents:	MO1-ints9 MO2-ints11
Observed In:	hemopoiesis
Stage Range:	5-9 somites to Prim-5

Phenotype Detail

Acknowledgments

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