FIGURE

Fig. 4

ID

ZDB-FIG-090714-4

Publication

Weiser et al., 2009 - Rho-regulated Myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation

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Fig. 4

Mesodermal cell polarity and migration are controlled by Mypt1. (A-C) The cell polarity of presomitic (B) and notochordal (C) mesodermal cells was determined by calculating the length-to-width (L/W) ratio (y-axis). (A) WT cells showing the long axis length and the short axis width. Note that mypt1 morphant cells are more rounded than the WT in both the notochord and presomitic mesoderm. (D,E) The migration ability of mesodermal cells was measured by tracking individual presomitic mesoderm cells at bud stage. Representative tracks of WT and morphant cells (D) are quantified (E). The y-axis displays dorsal movement in μm per hour; both total migration and net dorsal migration are shown. Note that morphant cells are more erratic in their movement and migrate less overall. ^*, P<0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WIK/AB + MO3-ppp1r12a
Knockdown Reagent:	MO3-ppp1r12a
Observed In:	notochord mesodermal cell segmental plate mesodermal cell
Stage:	Bud

Phenotype Detail

Acknowledgments

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