FIGURE

Fig. 8

ID

ZDB-FIG-081104-31

Publication

Laue et al., 2008 - Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

Loss of cyp26b1 and gain of Bmp signaling have different effects on the number and/or activity of osteoblasts. (A-K) In situ hybridization of zebrafish larvae of genotype indicated in upper right corners and with probes and at stages indicated at lower right corners. (A-I) Lateral views; (J,K) dorsal views. (A) Entire head; (B-E) opercle; (F-K) trunk at level of somites 6-10. In A, stronger cyp26b1 expression is seen in all craniofacial skeletogenic elements of the cyp26b1 mutant, but not in the dorsal brain. In G, perichordal opn-positive cells of the cyp26b1 mutant have largely given up their metameric distribution. (L) Average increase in the number of axial cyp26b1-(at 96 hpf), opn- or col10a1-positive cells (at 144 hpf) in the trunk/tail region of cyp26b1 mutants and heat-shocked Tg(hsp70:bmp2b) transgenic fish. Control wild-type (wt) siblings were set to a value of 1. Ten fish were counted per condition; standard errors are indicated. n, notochord.

Expression Data

Genes:	col10a1a cyp26b1 sp7 spp1
Fish:	WT cyp26b1^{ti230g/ti230g} fr13Tg
Condition:	heat shock
Anatomical Terms:	opercle osteoblast pharyngeal arch vertebra osteoblast
Stage Range:	Protruding-mouth to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development