Gene
cyp26b1
- ID
- ZDB-GENE-030131-2908
- Name
- cytochrome P450, family 26, subfamily b, polypeptide 1
- Symbol
- cyp26b1 Nomenclature History
- Previous Names
-
- dol
- fc21d03
- stocksteif (1)
- wu:fc21d03
- wu:fc26h10
- zgc:76999
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have C-22 sterol desaturase activity and retinoic acid 4-hydroxylase activity. Involved in several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and retinoic acid catabolic process. Predicted to localize to endoplasmic reticulum and endoplasmic reticulum membrane. Is expressed in several structures, including brain; cranium; hindbrain neural keel; pectoral fin; and pleuroperitoneal region. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Craniosynostosis with radiohumeral fusions and other skeletal and craniofacial anomalies | 614416 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| osteochondrodysplasia | cyp26b1ti230g/ti230g | standard conditions | Laue et al., 2011 |
| craniosynostosis | cyp26b1t24295/t24295 | standard conditions | Laue et al., 2011 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group IV | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A0R4I9F4
|
511 | ||||
|
UniProtKB:Q6EIG3
|
511 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp26b1-201
(1)
|
Ensembl | 3,869 nt | ||
| ncRNA |
cyp26b1-002
(1)
|
Ensembl | 579 nt |
Interactions and Pathways
No data available
Plasmids
No data available